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Project Leader: Mr Ben Turney, NIHR Clinical Lecturer

Ben is a Clinical Lecturer at Oxford researching kidney stone disease. Passing a renal stone is extremely painful. Unfortunately, those who develop kidney stones are likely to suffer recurrent episodes. At present little is known as to why a person will develop kidney stone disease and others will not. Current stone prevention strategies have so far proved to be ineffective. Therefore, identifying early markers of disease may help develop novel and effective kidney stone prevention strategies.

Proteomics is the study of expressed proteins at a given time under defined conditions, and is used to assess their functional and structural properties. Ben is using proteomic methods to study urinary proteins in urine samples collected from two groups, kidney stone and non-stone formers. Ben and his colleagues aim to highlight any differences in the composition and quantity of proteins between the two groups. The aim of this approach is to identify proteins that may be diagnostic or prognostic for stone disease and to develop strategies for reducing the risk of stone both in the short and long term.

2009

 PP Turney graph

  Weak cation exchange fractionation

  of 8 urine samples from controls.